赵美萍
教授，博士生导师
研究方向：分析化学
办公室：B333
电话：010-62758153
电子信箱：mpzhao@pku.edu.cn
课题组主页：http://www.chem.pku.edu.cn/mpzhao
学术简历：
· 2010 –至今 教授，北京大学化学与分子工程学院
· 2002 –2010 副教授，北京大学化学与分子工程学院
· 1998.7-1998.11 访问学者荷兰能源研究机构环境分析部
· 1997.9–1998.6 访问学者荷兰阿姆斯特丹大学环境与毒理化学系
· 2002 理学博士北京大学化学与分子工程学院
· 1993 理学硕士北京大学环境科学中心
· 1990 理学学士北京大学技术物理系
科研领域及兴趣：
本课题组致力于探索和构建新颖的分子识别体系，发展实时、在线的荧光分析方法，为生命科学研究、临床检验、环境监测和食品安全监控提供高效的分析测量手段。目前的主要研究方向：
(1) 细胞内核酸修复酶的荧光成像方法；
(2) 低丰度基因突变的超高灵敏检测及其在临床检验中的应用；
(3) 新型功能化分子识别新材料的设计、合成和应用；
(4) 外源基因的识别和定位方法。
代表性论文：
1. JQ Zhai, MH Zhao, XJ Cao, MY Li*, MP Zhao*, Metal-ion-responsive bionanocomposite for selective and reversible enzyme inhibition, Journal of the American Chemical Society, 2018, 140, 16925.
2. TB Wu, YF Yang, W Chen, JY Wang, ZY Yang, SL Wang, XJ Xiao, MY Li, MP Zhao*, Noncanonical substrate preference of lambda exonuclease for 5'-nonphosphate-ended dsDNA and a mismatch-induced acceleration effect on the enzymatic reaction, Nucleic Acids Research, 2018, 46, 3119.
3. TB Wu, W Chen, ZY Yang, HC Tan, JY Wang, XJ Xiao, MY Li, MP Zhao*, DNA terminal structure-mediated enzymatic reaction for ultra-sensitive discrimination of single nucleotide variations in circulating cell-free DNA, Nucleic Acids Research, 2018, 46(4), e24.
4. XJ Xiao, TB Wu, L Xu, W Chen, MP Zhao*, A branch-migration based fluorescent probe for straightforward, sensitive and specific discrimination of DNA mutations, Nucleic Acids Research, 2017, 45 (10): e90.
5. JQ Zhai, YB Liu, S Huang, SM Fang, MP Zhao*, A specific DNA-nanoprobe for optically tracking the activities of human apurinic/apyrimidinic endonuclease 1 in living cells, Nucleic Acids Research, 2017, 45(6), e45.
6. XJ Xiao, TB Wu, FD Gu, MP Zhao*, Generation of artificial sequence-specific nucleases via preassembled inert-template, Chemical Science, 2016, 7, 2051.
7. SM Fang, L Chen, MP Zhao*, Unimolecular chemically modified DNA fluorescent probe for one-step quantitative measurement of the activity of human apurinic/ apyrimidinic endonuclease 1 in biological samples, Analytical Chemistry, 2015, 87, 11952.
8. XJ Xiao, C Zhang, X Su, C Song, MP Zhao*, A universal mismatch-directed signal amplification platform for ultra-selective and sensitive DNA detection under mild isothermal conditions, Chemical Science, 2012, 3, 2257.
9. ZY Chen, L Xu, Y Liang, MP Zhao*, pH-Sensitive water-soluble nanospheric imprinted hydrogels prepared as horseradish peroxidase mimetic enzyme, Advanced Materials, 2010, 22, 1488.
10. C Song, MP Zhao*, Real-time monitoring of the activity and kinetics of T4 polynucleotide kinase by a singly labeled DNA-hairpin smart probe coupled with l exonuclease cleavage, Analytical Chemistry, 2009, 81, 1383.
英文网页：http://www.chem.pku.edu.cn/en/faculty/Faculty1/z/86542.htm
