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生物分离与质谱检测学术小组

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刘虎威

49833

刘虎威

博士,教授,博士生导师

北京大学化学与分子工程学院,

北京大学现代食品科技研究中心 主任

Tel:+86-10-62754976

Fax: +86-10-62751708

Email: hwliu@pku.edu.cn

Web: http://www.chem.pku.edu.cn/PAAL/ 

研究方向: 生物药物分离与检测,主要包括色谱(包括毛细管电泳)-质谱联用技术、敞开式离子化质谱技术、应用领域为生命组学分析、药物分析与临床分析。

中国化学会理事,中国化学会色谱专业委员会副主任,中国色谱学会常务理事;中国物理学会质谱学会副理事长;美国化学学会会员;中国分析测试协会理事、副秘书长,科学技术委员会委员。北京理化分析测试技术学会副理事长,北京色谱学会理事长;中国地质学会岩矿测试技术专业委员会副主任委员,中国仪器仪表学会分析仪器分会理事。《Journal of Separation Science》、《Journal of Analysis and Testing》、和《分析仪器》副主编,《色谱》执行副主编;《Analytical Chemistry》(2013-2015)和《Analytical and Bioanalytical Chemistry》国际编委,《Molecules》分析化学部编委;以及《化学通报 》、《中国药学. 英文版》、《分析试验室》、《分析科学学报》、《分析测试学报》、《现代科学仪器》、《现代仪器与医疗》、《岩矿测试》和《食品安全质量检测学报》编委。

学术简历:

1990.8 - 北京大学化学与分子工程学院,讲师/副教授/教授

1999.9-2001.2 法国南锡一大 合作研究

1996.7-1997.3 美国普渡大学化学系,BAS公司,交流学者

1995.9-1996.7 芬兰赫尔辛基大学化学系,交流学者

1984.9-1990.7 北京理工大学应用化学专业,硕士/博士学位

1978.10-1982.7 北京工业学院(现北京理工大学)高分子材料专业,学士学位

教学工作:

讲授研究生课程"高等色谱分析";

讲授研究生课程"现代分析化学";

讲授本科生课程"色谱分析";

指导硕士、博士研究生及国内进修教师

科研工作:

主要从事气相色谱、液相色谱、毛细管电泳,以及与质谱的联用技术方面的科研及教学工作,研究兴趣是生物药物分离与检测,包括色谱(毛细管电泳)-质谱联用技术、敞开式离子化质谱技术;应用领域涉及药物分析,组学分析,生物与临床分析。曾先后主持过国家自然科学基金委重点项目、科学仪器专项、面上项目、教育部回国人员基金项目、中法先进研究计划项目、科技部国家科技支撑计划项目、国家重大科技专项、教育部博士点基金项目,以及多项横向合作和国际合作项目。迄今发表有关论文240余篇,著作3部,并作为副主编参与了一套色谱技术丛书(第一版14册,第二版23册,化工出版社)的组织编写工作,获得第七届石油和化学工业优秀科技图书奖一等奖。曾获中国测试协会科技一等/二等/三等奖各一次。在色谱和毛细管电泳及其与质谱的联用技术方面积累了较为丰富的研究经验。在国内外学术会议上多次应邀作大会报告和邀请报告。至今培养博士研究生30多名。

Selected Publications (2012-2017):

Yang L, Lv P, Ai WP, Li LN, Shen SS, Nie HG, Shan YB, Bai Y, Huang YN*, Liu HW*, Lipidomic analysis of plasma in patients with lacunar infarction using normal-phase/reversed-phase two-dimensional liquid chromatography–quadrupole time-of-flight mass spectrometry, Anal. Bioanal. Chem., 2017, 409, 3211-3222

Li XJ, Wang X, Ma W, Ai WP, Bai Y, Ding L*, Liu HW*, Fast analysis of glycosides based on HKUST-1-coated monolith solid-phase microextraction and direct analysis in real-time mass spectrometry, J. Sep. Sci., 2017, 40, 1589-1596

Li LN, Shen SS, Lin R, Bai Y, Liu HW*, Rapid and Specific Luminescent Sensing of Cu(II) Ion with Porphyrinic Metal-Organic Framework, Rapid and Specific Luminescent Sensing of Cu(II) Ion with Porphyrinic Metal-Organic Framework, Chem. Comm., 2017, 53, 9986-9989

Li Z, Zhang JL, Zhang YD, Bai Y, Liu HW*, New strategy for further improving the detection sensitivity of direct analysis in real time mass spectrometry, J. Anal. Test., 2017, 1: 1-6

刘虎威*,白玉, 脂质组学及其分析方法, 色谱, 2017, 35, 86-90

Shen SS, Yang L, Li LN, Cai C*, Bai Y, Liu HW*, Plasma lipidomics reveals perturbed lipid metabolism and identifies potential lipid biomarkers of human colorectal cancer Beijing National Laboratory for Molecular Sciences, J. Chromatogr. B, 2017, 1068–1069, 41-48

Qi XY, Chang Z, Zhang D, Binder KJ, Shen SS, Huang YYS, Bai Y, Wheatley AEH,* Liu HW*, Harnessing Surface-Functionalized Metal−Organic Frameworks for Selective Tumor Cell Capture, Chem. Mater., 2017, 29, 8052-8056

Yang L, Bai Y, Han XH, Shi YK, Liu HW*,Lipidomic analysis of plasma in patients with hepatocellular carcinoma, J. Anal. Test., 2017, 1, 223-232

Li M, Yang L, Huang YN, Bai Y, Liu HW*, Sphingolipids profiling of plasma in patients with diabetes mellitus associated with atherosclerosis by a novel normal-phase UPLC-QToF MS method, J. Anal. Test., 2017, 1: 245-254

张一丁,徐姝婷,白玉,刘虎威*, 表面等离子体共振-质谱联用技术研究进展, 分析科学学报,2017, 33(5): 691-699

赵先恩, 白玉, 刘虎威*, 基于化学衍生化的靶向脂质组学质谱分析研究进展, 中国科学:化学》 SCIENTIA SINICA Chimica 10.1360/N032017-00121

Zhang Y, Xu ST, Wen LH, Bai Y*, Niu L, Song DQ, and Liu HW*, Dielectric barrier discharge ionization based interface for online coupling surface plasmon resonance with mass spectrometry, Analyst, 2016, 141, 3343–3348

Yang L, Li M, Shan YB, Shen SS, Bai Y, Liu HW*, Recent advances in lipidomics for disease research, 1Beijing National Laboratory for Molecular Sciences, J. Sep. Sci., 2016, 39, 38–50.

Zhang YD, Xu ST, Wen LH, Bai Y*, Niu L, Song DQ, Liu HW*, Dielectric barrier discharge ionization based interface for online coupling surface plasmon resonance with mass spectrometry, Analyst, 2016, 141, 3343–3348

Li XJ, Li Z, Wang X, Nie HG, Zhang YD, Bai Y*, Liu HW*, Monolith dip-it: a bifunctional device for improving the sensitivity of direct analysis in real time mass spectrometry, Analyst,2016, 141, 4947-4952

Li LN, Zhang YD, Li XJ, Shen SS, Huang HX, Bai Y, Liu HW*, Study on the interaction of uranyl with sulfated beta-cyclodextrin by affinity capillary electrophoresis and molecular dynamics simulation, Electrophoresis, 2016, 37, 2567–2573

Qi XY, Chen L, Zhang CQ, Xu XY, Zhang YD, Bai Y*, Liu HW*, NiCoMnO4: A Bifunctional Affinity Probe for Histagged Protein Purification and Phosphorylation Sites Recognition, ACS Applied Materials & Interfaces, 2016, 8, 18675-18683

Qi XY, Chang CL, Xu XY, Zhang YD, Bai Y, Liu HW*, Magnetization of 3D Homochiral MOFs for Efficient and Highly Selective Capture of Phosphopeptides, J. Chromatogr. A, 2016, 1468, 49–54

Xu ST, Zhang YD, Xu LN, Bai Y*, Liu HW*, Online Coupling Techniques in Ambient Mass Spectrometry, Analyst, 2016, 141, 5913-5921

Zhang YD, Ai WP, Bai Y*, Zhou YL, Wen LH, Zhang XX, Liu HW* An interface for online coupling capillary electrophoresis to dielectric barrier discharge ionization mass spectrometry, 1Beijing National Laboratory for Molecular Sciences, Anal. Bioanal. Chem., 2016, 408, 8655-8661

Li LN, Ma W, Shen SS, Huang HX, Bai Y, Liu HW*, A combined experimental and theoretical study on the extraction of uranium by amino-derived metal-organic frameworks through post-synthetic strategy, ACS Applied Materials & Interfaces, 2016, 8, 31032-31041

Chag CL, Qi XY, Zhang JW, Qiu YM, Li XJ, Wang X, Bai Y, Sun JL, Liu HW*, Facile synthesis of magnetic homochiral metal-organic frameworks for "enantioselective fishing'', Chem. Comm., 2015, 51, 3566-3569

Wang X, Li XJ, Bai Y*, Liu HW*, Just dip it: Just dip it: online coupling of “Dip-I” polymer monolith microextraction with plasma assisted laser desorption ionization mass spectrometry, Chem. Comm., 2015, 51, 4615-4618

Yang L, Cui XG, Zhang NN, Li M, Bai Y, Han XH, Shi YK*, Liu HW*, Comprehensive lipid profiling of plasma in patients with benign breast tumor and breast cancer reveals novel biomarkers, Anal. Bioanal. Chem., 2015, 407, 5065–5077

Zhang ZX, Bo T, Bai Y, Ye M, An R, Cheng FF, Liu HW*,Quadrupole time-of-flight mass spectrometry: powerful tool for demystifying traditional Chinese medicine, TrAC, 2015, 72, 169–180

Zhang YD, Li LN, Huang HX, Xu LN, Li Z, Bai Y and Liu HW*, Binding constant determination of uranyl-citrate complex by ACE using a multi-injection method, Electrophoresis, 2015, 36, 1033–1039

Zhang YD, Li XJ, Nie HG, Yang L, Li Z, Bai Y*, Niu L, Song DQ, Liu HW*, An Interface for On-line Coupling of Surface Plasmon Resonance to Direct Analysis in Real Time Mass Spectrometry, Anal. Chem., 2015, 87(13), 6505–6509

Weng R, Shen SS, Yang L, Li M, Tian YL, Bai Y* and Liu HW*, Lipidomic analysis of p-chlorophenylalanine-treated mice using continuous-flow two-dimensional liquid chromatography/quadrupole time-of-flight mass spectrometry, Rapid Commun. Mass Spectrom., 2015, 29, 1491-500

Li M, Yang L, Bai Y, Liu HW*, Analytical methods in lipidomics and their applications, Anal. Chem., 2014, 86, 161-175

Li XJ, Xing JW, Chang CL, Wang X, Bai Y, Yan XP and Liu HW*, Solid-phase extraction with the metal-organic framework MIL-101(Cr) combined with direct analysis in real time mass spectrometry for the fast analysis of triazine herbicides, J. Sep. Sci., 2014, 37, 1489-1495

Wang X, Li XJ, Li Z, Zhang YD, Bai Yi and Liu HW*, Online Coupling of In-tube Solid Phase Microextraction with Direct Analysis in Real Time Mass Spectrometry for Rapid Determination of Triazine Herbicides by Using Polymer Monolith Incorporated with Single-Wall Carbon Nanotubes, Anal. Chem., 2014, 86, 4739−4747

Bai Y, Chang CL, Du FY, Tan ZL, Bai Y, Liu HW*, Combination of dynamic pH junction with capillary electrophoresis-mass spectrometry for the determination of systemins in plant samples, Electrophoresis, 2014, 35, 1984-1988

Li XJ, Chang CL, Wang X, Bai Y and Liu HW*, Applications of homochiral metal-organic frameworks in enantioselective adsorption and chromatography separation, Electrophoresis, 2014, 35, 2733-2743

Pang NN, Bai Y, Zhou Y, Yang X, Zhang ZX, Nie HG, Fu XF, Liu HW*, Rapid and subnanomolar assay of recombinant human erythropoietin by capillary electrophoresis using NanoOrange precolumn labeling and laser-induced fluorescence detection, J. Sep. Sci., 2014, 37, 2233-2238

Liu YQ, Zhang JL, Nie HG, Dong CX, Li Z, Zhang ZG, Bai Y, Liu HW* and Zhang JD*, Study on Variation of Lipids during Different Growth Phases of Living Cyanobacteria Using Easy Ambient Sonic-Spray Ionization Mass Spectrometry, Anal. Chem., 2014, 86, 7096-7102

Li Z, Zhang YW, Xin YL, Bai Y*, Zhou HH, Liu HW*,Lithium-rich composite metal oxide used as SALDI-MS matrix for the determination of small biomolecules, Chem, Comm., 2014, 50 (97), 15397-15399

Li M, Tang XL, Lv Pm Fang BS, Yang L, Wu Z, Cui XG, Bai Y, Huang YN* and Liu HW*,A not-stop-flow online normal-/reversed-phase two-dimensional liquid chromatography-quadrupole time-of-flight mass spectrometry method for comprehensive lipid profiling of human plasma from atherosclerosis patients, J. Chromatogr. A, 2014, 1372, 110-119

Li LP, Zheng T, Xu LN, Li Z, Sun LD, Nie ZX, Bai Y*, Liu, HW*, SnO2-ZnSn(OH)(6): a novel binary affinity probe for global phosphopeptide detection. Chem. Comm., 2013, 49, 1762-1764.

Chang CL, Xu GG, Bai Y*, Zhang CS, Li XJ, Li M, Liu Y, Liu HW*, Online Coupling of Capillary Electrophoresis with Direct Analysis in Real Time Mass Spectrometry. Anal. Chem., 2013, 8, 170-176.

Wang X, Ma Q, Li M, Chang CL, Bai Y, Feng YQ, Liu HW*, Automated and sensitive analysis of 28-epihomobrassinolide in Arabidopsis thaliana by on-line polymer monolith microextraction coupled to liquid chromatography-mass spectrometry. J. Chromatogr. A, 2013, 1371, 121-128.

Chang CL, Li XJ, Bai Y*, Xu GG, Feng BS, Liao YP, Liu HW*, Graphene matrix for signal enhancement in ambient plasma assisted laser desorption ionization mass spectrometry, Talanta, 2013, 114, 54-59.

Li M, Feng BS, Liang Y, Zhang W, Bai Y, Liu HW*, Lipid profiling of human plasma from peritoneal dialysis patients using an improved 2D (NP/RP) LC-QToF MS method. Anal. Bioanal. Chem., 2013, 405, 6629–6638

Chang CL, Wang X, Bai Y, Liu HW*, Applications of nanomaterials in enantioseparation and related techniques. TrAC-Trends in Anal. Chem., 2012, 39, 195-206.

Zhang JL, Li Z, Zhang CS, Feng BS, Zhou ZG, Bai Y, Liu HW*, Graphite-Coated Paper as Substrate for High Sensitivity Analysis in Ambient Surface-Assisted Laser Desorption/Ionization Mass Spectrometry. Anal. Chem., 2012, 84, 3296-3301.

Han YH, Zhou ZG, Wu HL, Nie HG, Lei R, Bai Y, Liu HW*, Simultaneous determination of jasmonic acid epimers as phytohormones by chiral liquid chromatography-quadrupole time-of-flight mass spectrometry and their epimerization study, J. Chromatogr. A, 012, 1235, 125-131.

Zhou ZG, Yang YY, Zhang JL, Zhang ZX, Bai Y, Liao YP, Liu HW*, Ion-exchange-membrane-based enzyme micro-reactor coupled online with liquid chromatography-mass spectrometry for protein analysis. Anal. Bioanal. Chem., 2012, 403, 239-246.

Chang CL, Zhou ZG, Yang YY, Han YH, Bai Y, Zhao MP, Liu HW*, Normal phase LC coupled with direct analysis in real time MS for the chiral analysis of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and jasmonic acid . Electrophoresis. 2012, 33, 3387-3393

Zhou ZG, Zhang ZL, Xing JW, Bai Y, Liao YP, Liu HW*, Membrane-Based Continuous Remover of Trifluoroacetic Acid in Mobile Phase for LC-ESI-MS Analysis of Small Molecules and Proteins. J. Am. Soc. Mass Spectrom., 2012, 23,1289-1292


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